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Graphical contents list • CONTENTS LIST PDF (1012 K) | |||
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Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase • SHORT COMMUNICATION Philip Reigan, Abdul Gbaj, Edwin Chinje, Ian J. Stratford, Kenneth T. Douglas and Sally Freeman SummaryPlus | Full Text + Links | PDF (280 K) | |||
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Synthesis and structure–activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists • SHORT COMMUNICATION Nalan Terzioglu, Richard M. van Rijn, Remko A. Bakker, Iwan J.P. De Esch and Rob Leurs SummaryPlus | Full Text + Links | PDF (302 K) | |||
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Optimizing the antibacterial activity of a lead structure discovered by ‘SAR by MS’ technology • SHORT COMMUNICATION Elizabeth A. Jefferson, Punit P. Seth, Dale E. Robinson, Dana K. Winter, Alycia Miyaji, Lisa M. Risen, Stephen A. Osgood, Myra Bertrand and Eric E. Swayze SummaryPlus | Full Text + Links | PDF (326 K) | |||
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SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa • SHORT COMMUNICATION Joanne M. Smallheer, Richard S. Alexander, Jianmin Wang, Shuaige Wang, Suanne Nakajima, Karen A. Rossi, Angela Smallwood, Frank Barbera, Debra Burdick, Joseph M. Luettgen et al. SummaryPlus | Full Text + Links | PDF (331 K) | |||
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5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa • SHORT COMMUNICATION Douglas G. Batt, Jennifer X. Qiao, Dilip P. Modi, Gregory C. Houghton, Deborah A. Pierson, Karen A. Rossi, Joseph M. Luettgen, Robert M. Knabb, P.K. Jadhav and Ruth R. Wexler SummaryPlus | Full Text + Links | PDF (302 K) | |||
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Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor • SHORT COMMUNICATION Zhengming Chen, Ellen Davies, Wendy S. Miller, Shen Shan, Kenneth J. Valenzano and Donald J. Kyle SummaryPlus | Full Text + Links | PDF (280 K) | |||
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Novel aryloxy-8-azabicyclo[3.2.1]oct-3-enes with 5-HT transporter and 5-HT1A affinity • SHORT COMMUNICATION Adam M. Gilbert, Thomas Coleman, Jason Kodah, Richard E. Mewshaw, Rosemary Scerni, Lee E. Schechter, Deborah L. Smith and Terrance H. Andree SummaryPlus | Full Text + Links | PDF (266 K) | |||
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Synthesis and structure–activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands • SHORT COMMUNICATION Marcian E. Van Dort and Yong-Woon Jung SummaryPlus | Full Text + Links | PDF (260 K) | |||
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Synthesis and antiproliferative activity of 2-aryl-4-oxo-thiazolidin-3-yl-amides for prostate cancer • SHORT COMMUNICATION Veeresa Gududuru, Eunju Hurh, James T. Dalton and Duane D. Miller SummaryPlus | Full Text + Links | PDF (271 K) | |||
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Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group • SHORT COMMUNICATION Sui Xiong Cai, Lufeng Guan, Shaojuan Jia, Yan Wang, Wu Yang, Ben Tseng and John Drewe SummaryPlus | Full Text + Links | PDF (282 K) | |||
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More potent linear peptide inhibitors of mammalian ribonucleotide reductase • SHORT COMMUNICATION Chiheng Tan, Ying Gao, Jaskiran Kaur and Barry S. Cooperman SummaryPlus | Full Text + Links | PDF (258 K) | |||
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Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors • SHORT COMMUNICATION Toshio Nakamura, Takaaki Ishii, Noriyuki Miyata, Kazuo Taniguchi, Yasumitsu Tomishima, Tomokazu Ueki and Masakazu Sato SummaryPlus | Full Text + Links | PDF (305 K) | |||
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Substrate analogs for the investigation of deoxyxylulose 5-phosphate reductoisomerase inhibition: synthesis and evaluation • SHORT COMMUNICATION Chanokporn Phaosiri and Philip J. Proteau SummaryPlus | Full Text + Links | PDF (271 K) | |||
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Fluorescent sodium ion indicators based on the 1,7-diaza-15-crown-5 system • SHORT COMMUNICATION Vladimir V. Martin, Anca Rothe, Zhenjun Diwu and Kyle R. Gee SummaryPlus | Full Text + Links | PDF (285 K) | |||
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Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment • SHORT COMMUNICATION Ayako Yamashita, Emily B. Norton, Joshua A. Kaplan, Chuan Niu, Frank Loganzo, Richard Hernandez, Carl F. Beyer, Tami Annable, Sylvia Musto, Carolyn Discafani et al. SummaryPlus | Full Text + Links | PDF (312 K) | |||
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Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors • SHORT COMMUNICATION Yong Xu, Masayuki Tanaka, Hiroyuki Arai, Junken Aoki and Glenn D. Prestwich SummaryPlus | Full Text + Links | PDF (298 K) | |||
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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones • SHORT COMMUNICATION Anthony B. Pinkerton, Rowena V. Cube, John H. Hutchinson, Blake A. Rowe, Hervé Schaffhauser, Xiumin Zhao, Lorrie P. Daggett and Jean-Michel Vernier SummaryPlus | Full Text + Links | PDF (266 K) | |||
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HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY • SHORT COMMUNICATION Constantin G. Yannopoulos, Ping Xu, Feng Ni, Laval Chan, Oswy Z. Pereira, T. Jagadeeswar Reddy, Sanjoy K. Das, Carl Poisson, Nghe Nguyen-Ba, Nathalie Turcotte et al. SummaryPlus | Full Text + Links | PDF (465 K) | |||
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Three new compounds from the plant Lippia alva as inhibitors of chemokine receptor 5 (CCR5) • SHORT COMMUNICATION Vinod R. Hegde, Haiyan Pu, Mahesh Patel, Pradip R. Das, Julie Strizki, Vincent P. Gullo, Chuan-Chu Chou, Alexei V. Buevich and Tze-Ming Chan SummaryPlus | Full Text + Links | PDF (280 K) | |||
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Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones • SHORT COMMUNICATION Binoy Jose, Yusuke Oniki, Tamaki Kato, Norikazu Nishino, Yuko Sumida and Minoru Yoshida SummaryPlus | Full Text + Links | PDF (274 K) | |||
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Bis[3-(4′-substituted phenyl)prop-2-ene]disulfides as a new class of antihyperlipidemic compounds • SHORT COMMUNICATION Meenakshi Sharma, Manisha Tiwari and Ramesh Chandra SummaryPlus | Full Text + Links | PDF (266 K) | |||
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Synthesis of some newer analogues of substituted dibenzoyl phenol as potent anti-inflammatory agents • SHORT COMMUNICATION Shaukath Ara. Khanum, Venu T. D, Sheena Shashikanth and Aiysha Firdouse SummaryPlus | Full Text + Links | PDF (272 K) | |||
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In vitro plasma protein binding and aqueous aggregation behavior of astaxanthin dilysinate tetrahydrochloride • SHORT COMMUNICATION Ferenc Zsila, Ilona Fitos, Zsolt Bikádi, Miklós Simonyi, Henry L. Jackson and Samuel F. Lockwood SummaryPlus | Full Text + Links | PDF (551 K) | |||
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Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors • SHORT COMMUNICATION Qun Li, Akiyo Claiborne, Tongmei Li, Lisa Hasvold, Vincent S. Stoll, Steven Muchmore, Clarissa G. Jakob, Wendy Gu, Jerry Cohen, Charles Hutchins et al. SummaryPlus | Full Text + Links | PDF (341 K) | |||
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Synthesis and activity of 1-aryl-1′-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors • SHORT COMMUNICATION Qun Li, Gary T. Wang, Tongmei Li, Stephen L. Gwaltney II, Keith W. Woods, Akiyo Claiborne, Xilu Wang, Wendy Gu, Jerry Cohen, Vincent S. Stoll et al. SummaryPlus | Full Text + Links | PDF (356 K) | |||
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Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction • SHORT COMMUNICATION Govindarajan Manikumar,Randy M. Wadkins, David Bearss, Daniel D. Von Hoff, Mansukhlal C. Wani and Monroe E. Wall SummaryPlus | Full Text + Links | PDF (315 K) | |||
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A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis • SHORT COMMUNICATION Dearg S. Brown, Andrew J. Belfield, George R. Brown, Douglas Campbell, Alan Foubister, David J. Masters, Kurt G. Pike, Wendy L. Snelson and Stuart L. Wells SummaryPlus | Full Text + Links | PDF (276 K) | |||
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Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase • SHORT COMMUNICATION John G. Cumming, Caroline L. McKenzie, Stuart G. Bowden, Douglas Campbell, David J. Masters, Jason Breed and Philip J. Jewsbury SummaryPlus | Full Text + Links | PDF (370 K) | |||
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Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake • SHORT COMMUNICATION J.R. Boot, G. Brace, C.L. Delatour, N. Dezutter, J. Fairhurst, J. Findlay, P.T. Gallagher, I. Hoes, S. Mahadevan, S.N. Mitchell et al. SummaryPlus | Full Text + Links | PDF (291 K) | |||
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Synthesis and biological evaluation of thiazolidine-2,4-dione and 2,4-thione derivatives as inhibitors of translation initiation • SHORT COMMUNICATION Han Chen, Yun-Hua Fan, Amarnath Natarajan, Yuhong Guo, Julia Iyasere, Fred Harbinski, Lia Luus, William Christ, Huseyin Aktas and Jose A. Halperin SummaryPlus | Full Text + Links | PDF (283 K) | |||
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Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives • SHORT COMMUNICATION Minoru Imai, Tatsuki Shiota, Ken-ichiro Kataoka, Christine M. Tarby, Wilna J. Moree, Takaharu Tsutsumi, Masaki Sudo, Michele M. Ramirez-Weinhouse, Daniel Comer, Chung-Ming Sun et al. SummaryPlus | Full Text + Links | PDF (301 K) | |||
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Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure–activity relationships of diamine derivatives • SHORT COMMUNICATION Wilna J. Moree, Ken-ichiro Kataoka, Michele M. Ramirez-Weinhouse, Tatsuki Shiota, Minoru Imai, Masaki Sudo, Takaharu Tsutsumi, Noriaki Endo, Yumiko Muroga, Takahiko Hada et al. SummaryPlus | Full Text + Links | PDF (273 K) | |||
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Effect of γ-hydroxypropano deoxyguanosine, the major acrolein-derived adduct, on monomolecular quadruplex structure of telomeric repeat d(TTAGGG)4 • SHORT COMMUNICATION Giuliana D’Isa, Aldo Galeone, Giorgia Oliviero, Gennaro Piccialli, Michela Varra and Luciano Mayol SummaryPlus | Full Text + Links | PDF (418 K) | |||
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Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine • SHORT COMMUNICATION Claire Mazier, Maryse Jaouen, Marie-Agnès Sari and Didier Buisson SummaryPlus | Full Text + Links | PDF (253 K) | |||
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Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties • SHORT COMMUNICATION Vladimir Garaj, Luca Puccetti, Giuseppe Fasolis, Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, Daniela Vullo, Alessio Innocenti and Claudiu T. Supuran SummaryPlus | Full Text + Links | PDF (291 K) | |||
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Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions • SHORT COMMUNICATION Alessio Innocenti, Jonna M. Lehtonen, Seppo Parkkila, Andrea Scozzafava and Claudiu T. Supuran SummaryPlus | Full Text + Links | PDF (263 K) | |||
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New N-pyridinyl(methyl)-indolalkanamides acting as topical inflammation inhibitors • SHORT COMMUNICATION Alexandra Dassonville, Anne Bretéché, Johan Evano, Muriel Duflos, Guillaume le Baut, Nicole Grimaud and Jean-Yves Petit SummaryPlus | Full Text + Links | PDF (266 K) | |||
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Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors • SHORT COMMUNICATION Paul Beswick, Sharon Bingham, Chas Bountra, Terry Brown, Kerry Browning, Ian Campbell, Iain Chessell, Nick Clayton, Sue Collins, John Corfield et al. SummaryPlus | Full Text + Links | PDF (263 K) | |||
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Corrigendum to “Synthesis, characterization, and evaluation of pro-drugs of VLA-4 antagonists”: [Bioorg. Med. Chem. Lett. 14 (2004) 1651] • ERRATUM D.M. Huryn, Susan Ashwell, Reinhardt Baudy, Darren B. Dressen, William Gallaway, Francine S. Grant, Andrei Konradi, Robert W. Ley, Susan Petusky, Michael A. Pleiss et al. SummaryPlus | Full Text + Links | PDF (206 K) | |||
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Editorial board • EDITORIAL BOARD PDF (391 K) | |||
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Contributors to this issue • INDEX PDF (188 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (74 K) | |||
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